General Overview
Salmonella, a genus of rodshaped, gramnegative, nonspore forming, and predominantly motile enterobacteria, causes more than 10^{4} cases of infections per year in United States. Salmonellosis is an important medical problem, as well as infection with nontyphi Salmonella which often causes mild selflimited illness, Severe sequelae including death may occur, particularly in immunocompromised hosts. It has been reported that the incidence of salmonellosis is higher in developing countries, where food handlers may be a reservoir for further transmission of infection. ^{[1]}
Salmonella anatum is a common cause of salmonellosis, an important infectious disease in humans and animals. ^{[2]} Additionally, unpasteurized fruit juices have been associated with outbreaks of gastrointestinal diseases caused by infection with Salmonella anatum ^{[3]}
Summary Data
McCullough, N. B. and C. W. Elsele (1951) inoculated human volunteers orally with the Salmonella anatum strain I,II and III.^{[4]}
Recommended Model
The pooled model of experiment number 232 and 233 is the recommended model as more data points in the model result into improvement in fits.
ID  # of Doses  Agent Strain  Dose Units  Host type  Μodel  Optimized parameters  Response type  Reference  

232  8  strain I  CFU  human  betaPoisson 
a = 2.91E01 LD_{50}/ID_{50} = 4.44E+04 N_{50} = 4.44E+04 
positive stool culture  Experimental Human Salmonellosis: I  
232, 233  16  strain I  CFU  human  betaPoisson 
a = 3.18E01 LD_{50}/ID_{50} = 3.71E+04 N_{50} = 3.71E+04 
positive stool culture  
233  8  strain II  CFU  human  betaPoisson 
a = 2.3E01 LD_{50}/ID_{50} = 4.91E+03 N_{50} = 4.91E+03 
positive stool culture  Experimental Human Salmonellosis: I 
LD_{50}/ID_{50} = 4.44E+04
N_{50} = 4.44E+04



Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model
LD_{50}/ID_{50} = 3.71E+04
N_{50} = 3.71E+04



Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model
LD_{50}/ID_{50} = 4.91E+03
N_{50} = 4.91E+03



Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model