@article {1820,
	title = {Quantification of the {Effects} of {Age} on the {Dose} {Response} of {{Variola} major in {Suckling} {Mice}},
	journal = {Human and Ecological Risk Assessment: An International Journal},
	volume = {15},
	year = {2009},
	pages = {1245{\textendash}1256},
	abstract = {<p>Dose-response data for Variola major (V. major), the causative agent of smallpox, were obtained from the open literature, summarized, and fitted with three doseresponse models. It is known from prior outbreak experience that there is generally a difference in infectivity of the agent and its subsequent mortality depending on the age of the patient. A source of animal dose-response data were found with age delineation for the exposure group (suckling mice, intraperitoneal exposure). This delineation was used to adapt current dose-response models to include an age dependency parameter. The degree of the models{\textquoteright} fit to the data was ascertained using maximum likelihood estimation (MLE). The effect of host age could be described quantitatively using modifications to the beta Poisson and exponential dose-response models. The modifications improvement in the accuracy of risk prediction by 72\% for the beta Poisson model and 7\% for the exponential model, compared to the original (unmodified) models.</p>
},
	issn = {1080-7039, 1549-7860},
	doi = {10.1080/10807030903304906},
	url = {http://www.tandfonline.com/doi/full/10.1080/10807030903304906},
	author = {Weir, Mark H. and Haas, Charles N.}
}
@book {1807,
	title = {Quantitative Microbial Risk Assessment},
	year = {2014},
	publisher = {John Wiley \& Sons},
	organization = {John Wiley \& Sons},
	abstract = {<p>Provides the latest QMRA methodologies to determine infection risk cause by either accidental microbial infections or deliberate infections caused by terrorism {\textbullet}\&nbsp;Reviews the latest methodologies to quantify at every step of the microbial exposure pathways, from the first release of a pathogen to the actual human infection {\textbullet}\&nbsp;Provides techniques on how to\&nbsp; gather information, on how each microorganism moves through the environment, how to determine their survival rates on various media, and how people are exposed to the microorganism {\textbullet}\&nbsp;Explains how QMRA can be used as a tool to measure the impact of interventions and identify the best policies and practices to protect public health and safety {\textbullet}\&nbsp;Includes new information on genetic methods {\textbullet}\&nbsp;Techniques use to develop risk models for drinking water, groundwater, recreational water, food and pathogens in the indoor environment</p>
},
	isbn = {978-1-118-14529-6},
	author = {Haas, Charles N. and Rose, Joan B. and Gerba, Charles P.}
}
