Host type
# of Doses
10.00
Μodel
a
3.28E-01
N50
5.43E+03
LD50/ID50
5.43E+03
Dose Units
Response
Agent Strain
KHW,316c
Experiment Dataset
Description: 

Optimization Output for experiment 18 and 23 pooled (B. pseudomallei)

Pooled data of C57BL/6 mice and diabetic rat [1]
Dose DEATH NOT DEATH Total
150 0 6 6
450 1 5 6
1350 1 5 6
3000 6 4 10
4050 3 3 6
12200 3 3 6
3E+04 7 3 10
3E+05 7 3 10
3E+06 10 0 10
3E+07 10 0 10

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom
χ20.95,1 
p-value
χ20.95,m-k 
p-value
Exponential 63.3 56.6 9 3.84 
5.42e-14
16.9 
3.15e-10
Beta Poisson 6.68 8 15.5 
0.571
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 3.28E-01 1.94E-01 2.16E-01 2.31E-01 5.15E-01 5.86E-01 8.32E-01
N50 5.43E+03 1.82E+03 2.37E+03 2.64E+03 1.23E+04 1.39E+04 1.68E+04

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

 

beta Poisson model plot, with confidence bounds around optimized model


References