SARS coronavirus

From QMRAwiki
Revision as of 20:57, 10 July 2012 by GeurinZa (talk | contribs)
Jump to: navigation, search

SARS coronavirus (Severe Acute Respiratory Syndrome)

Hosts

Humans

Transmission/Exposure Routes

Primarily via close person-to-person contact, through droplet transmission [1]

Incubation Times

Maximum is 10 days [2]

Case Fatality Ratios

Less than 1% for people aged 24 or younger, 6% for those 25 to 44, 15% for those 45 to 64, and more than 50% for those over 65[2]

Case Fatality Ratios
Age (Years) Case Fatality Ratio
< 24 < 1%
25-44 6%
45-64 15%
> 65 > 50%

Burden of Disease

In the 2002-2003 outbreak, more than 8,000 cases were identified, mostly in mainland China. North America saw 251 cases during that period [3]

Duration of Infectiousness and disease

Symptomology

A high fever is typical (upwards of 38°C) at onset, after which headaches, general malaise, and diarrhea can occur. After 2 to 7 days, a dry cough may develop. Pneumonia is typical of most SARS patients.[4]

Latency

Asymptomatic Rates

Excretion Rates (see Exposure)

Immunity

Microbiology

Coronaviruses are positive-strand, enveloped RNA viruses [5]

Recommended Dose Response Model


Dose response models for SARS
Exponential, k is 2.46E-03
Exponential model.png




References

  1. Medscape
  2. 2.0 2.1 Update 49 - SARS case fatality ratio, incubation period, World Health Organization, 7 May 2003. URL Accessed 17 May 2008. Full text
  3. Trivendi, M. Pinsky, M. (2011) “Severe Acute Respiratory Syndrome (SARS)" Medscape Reference. Retrieved on 1-31-12 from http://emedicine.medscape.com/article/237755-overview#a0156
  4. Center For Disease Control Full Text
  5. Wikipedia