Difference between revisions of "SARS coronavirus"

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=='''''SARS coronavirus''''' (Severe Acute Respiratory Syndrome)==
 
=='''''SARS coronavirus''''' (Severe Acute Respiratory Syndrome)==
http://www.cdc.gov/sars/index.html
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===Hosts===
 
===Hosts===
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===Transmission/Exposure Routes===
 
===Transmission/Exposure Routes===
Primarily via close person-to-person contact, through droplet transmission ([http://emedicine.medscape.com/article/237755-overview#showall Medscape])
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Primarily via close person-to-person contact, through droplet transmission <ref name=Medscape>[http://emedicine.medscape.com/article/237755-overview#showall Medscape]</ref>
  
 
===Incubation Times===
 
===Incubation Times===
Maximum is 10 days (Update 49)
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Maximum is 10 days <ref name=Update>Update 49 - SARS case fatality ratio, incubation period, World Health Organization, 7 May 2003. URL Accessed 17 May 2008. [http://www.who.int/csr/sarsarchive/2003_05_07a/en/# Full text]</ref>
  
 
===Case Fatality Ratios===
 
===Case Fatality Ratios===
Less than 1% for people aged 24 or younger, 6% for those 25 to 44, 15% for those 45 to 64, and more than 50% for those over 65 (Update 49)
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Less than 1% for people aged 24 or younger, 6% for those 25 to 44, 15% for those 45 to 64, and more than 50% for those over 65<ref name=Update></ref>
 
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===Burden of Disease===
 
===Burden of Disease===
In the 2002-2003 outbreak, more than 8,000 cases were identified, mostly in mainland China.  North America saw 251 cases during that period (Trivendi, M. 2011).
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In the 2002-2003 outbreak, more than 8,000 cases were identified, mostly in mainland China.  North America saw 251 cases during that period <ref name=Trivendi>
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Trivendi, M. Pinsky, M. (2011) “Severe Acute Respiratory Syndrome (SARS)"  Medscape Reference. Retrieved on 1-31-12 from http://emedicine.medscape.com/article/237755-overview#a0156</ref>
  
 
====Duration of Infectiousness and disease====
 
====Duration of Infectiousness and disease====
 
====Symptomology====
 
====Symptomology====
A high fever is typical (upwards of 38°C) at onset, after which headaches, general malaise, and diarrhea can occur.  After 2 to 7 days, a dry cough may develop.  Pneumonia is typical of most SARS patients. <ref> http://www.cdc.gov/sars/about/fs-SARS.html CDC </ref>
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A high fever is typical (upwards of 38°C) at onset, after which headaches, general malaise, and diarrhea can occur.  After 2 to 7 days, a dry cough may develop.  Pneumonia is typical of most SARS patients.<ref name=CDC>Center For Disease Control [http://www.cdc.gov/sars/about/fs-SARS.html Full Text]</ref>
  
 
====Latency====
 
====Latency====
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===Microbiology===
 
===Microbiology===
Coronaviruses are positive-strand, enveloped RNA viruses ([http://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome Wikipedia])
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Coronaviruses are positive-strand, enveloped RNA viruses <ref name=Wikipedia>[http://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome Wikipedia]</ref>
  
 
===Recommended Dose Response Model===
 
===Recommended Dose Response Model===
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===References===
 
===References===
 
<references />
 
<references />
 
Trivendi, M. Pinsky, M. (2011) “Severe Acute Respiratory Syndrome (SARS)"  Medscape Reference. Retrieved on 1-31-12 from http://emedicine.medscape.com/article/237755-overview#a0156
 
http://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome <br />
 
http://emedicine.medscape.com/article/237755-overview#showall <br />
 
Update 49 - SARS case fatality ratio, incubation period, World Health Organization, 7 May 2003. URL Accessed 17 May 2008. [http://www.who.int/csr/sarsarchive/2003_05_07a/en/# Full text] <br />
 
Center For Disease Control [http://www.cdc.gov/sars/about/fs-SARS.html Full Text] <br />
 
 
  
 
[[Category:PSDS]][[Category:Virus]]
 
[[Category:PSDS]][[Category:Virus]]

Revision as of 20:57, 10 July 2012

SARS coronavirus (Severe Acute Respiratory Syndrome)

Hosts

Humans

Transmission/Exposure Routes

Primarily via close person-to-person contact, through droplet transmission [1]

Incubation Times

Maximum is 10 days [2]

Case Fatality Ratios

Less than 1% for people aged 24 or younger, 6% for those 25 to 44, 15% for those 45 to 64, and more than 50% for those over 65[2]

Case Fatality Ratios
Age (Years) Case Fatality Ratio
< 24 < 1%
25-44 6%
45-64 15%
> 65 > 50%

Burden of Disease

In the 2002-2003 outbreak, more than 8,000 cases were identified, mostly in mainland China. North America saw 251 cases during that period [3]

Duration of Infectiousness and disease

Symptomology

A high fever is typical (upwards of 38°C) at onset, after which headaches, general malaise, and diarrhea can occur. After 2 to 7 days, a dry cough may develop. Pneumonia is typical of most SARS patients.[4]

Latency

Asymptomatic Rates

Excretion Rates (see Exposure)

Immunity

Microbiology

Coronaviruses are positive-strand, enveloped RNA viruses [5]

Recommended Dose Response Model


Dose response models for SARS
Exponential, k is 2.46E-03
Exponential model.png




References

  1. Medscape
  2. 2.0 2.1 Update 49 - SARS case fatality ratio, incubation period, World Health Organization, 7 May 2003. URL Accessed 17 May 2008. Full text
  3. Trivendi, M. Pinsky, M. (2011) “Severe Acute Respiratory Syndrome (SARS)" Medscape Reference. Retrieved on 1-31-12 from http://emedicine.medscape.com/article/237755-overview#a0156
  4. Center For Disease Control Full Text
  5. Wikipedia