PrP prion

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Human and animal [1]

Primary method of infection in animals is through ingestion[2]

Incubation periods of infection with human prions can exceed 50 years[3]

Prion-related diseases are relentlessly progressive and invariably lead to death. [2]

The most common prion disease is CJD, with a uniform incidence of approximately 1 case per million population both in the United States and internationally[2]

Duration of Infectiousness and disease



Asymptomatic Rates

Excretion Rates (see Exposure)


An infectious agent composed of protein in a misfolded form


  1. CDC
  2. 2.0 2.1 2.2 Medscape
  3. John Collinge, Jerome Whitfi eld, Edward McKintosh, John Beck, Simon Mead, Dafydd J Thomas, Michael P Alpers. (2006) Kuru in the 21st century—an acquired human prion disease with very long incubation periods. Lancet. 367: 2068–74. Full Text