Difference between revisions of "PrP prion"

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=='''''Prion''''' (Prion Diseases)==
 
=='''''Prion''''' (Prion Diseases)==
http://www.cdc.gov/ncidod/dvrd/prions/
 
  
 
===Hosts===
 
===Hosts===
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===Transmission/Exposure Routes===
 
===Transmission/Exposure Routes===
Primary method of infection in animals is through ingestion ([http://emedicine.medscape.com/article/1168941-overview#showall Medscape])
+
Primary method of infection in animals is through ingestion<ref name=Medscape>[http://emedicine.medscape.com/article/1168941-overview#showall Medscape]</ref>
  
 
===Incubation Times===
 
===Incubation Times===
Incubation periods of infection with human prions can exceed 50 years (Collinge et al, 2006)
+
Incubation periods of infection with human prions can exceed 50 years<ref name=Collinge>John Collinge, Jerome Whitfi eld, Edward McKintosh, John Beck, Simon Mead, Dafydd J Thomas, Michael P Alpers. (2006) Kuru in the 21st century—an acquired human prion disease
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with very long incubation periods. Lancet. 367: 2068–74. [http://www.sciencedirect.com.proxy1.cl.msu.edu/science?_ob=MiamiImageURL&_cid=271074&_user=1111158&_pii=S0140673606689307&_check=y&_origin=&_coverDate=30-Jun-2006&view=c&wchp=dGLbVBA-zSkWA&md5=4cf4946d5669da97178c506ee474f5a9/1-s2.0-S0140673606689307-main.pdf Full Text]</ref>
  
 
===Case Fatality Ratios===
 
===Case Fatality Ratios===
Prion-related diseases are relentlessly progressive and invariably lead to death ([http://emedicine.medscape.com/article/1168941-overview#showall Medscape]).
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Prion-related diseases are relentlessly progressive and invariably lead to death. <ref name=Medscape></ref>
  
 
===Burden of Disease===
 
===Burden of Disease===
The most common prion disease is CJD, with a uniform incidence of approximately 1 case per million population both in the United States and internationally ([http://emedicine.medscape.com/article/1168941-overview#showall Medscape])
+
The most common prion disease is CJD, with a uniform incidence of approximately 1 case per million population both in the United States and internationally<ref name=Medscape></ref>
 
====Duration of Infectiousness and disease====
 
====Duration of Infectiousness and disease====
 
====Symptomology====
 
====Symptomology====
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===References===
 
===References===
http://emedicine.medscape.com/article/1168941-overview#showall <br />
+
http://www.cdc.gov/ncidod/dvrd/prions/ <br />
John Collinge, Jerome Whitfi eld, Edward McKintosh, John Beck, Simon Mead, Dafydd J Thomas, Michael P Alpers. (2006) Kuru in the 21st century—an acquired human prion disease
+
<references />
with very long incubation periods. Lancet. 367: 2068–74. [http://www.sciencedirect.com.proxy1.cl.msu.edu/science?_ob=MiamiImageURL&_cid=271074&_user=1111158&_pii=S0140673606689307&_check=y&_origin=&_coverDate=30-Jun-2006&view=c&wchp=dGLbVBA-zSkWA&md5=4cf4946d5669da97178c506ee474f5a9/1-s2.0-S0140673606689307-main.pdf Full Text] <br />
 
 
 
 
[[Category:PSDS]][[Category:Prion]]
 
[[Category:PSDS]][[Category:Prion]]

Revision as of 17:43, 10 July 2012

Prion (Prion Diseases)

Hosts

Human and animal

Transmission/Exposure Routes

Primary method of infection in animals is through ingestion[1]

Incubation Times

Incubation periods of infection with human prions can exceed 50 years[2]

Case Fatality Ratios

Prion-related diseases are relentlessly progressive and invariably lead to death. [1]

Burden of Disease

The most common prion disease is CJD, with a uniform incidence of approximately 1 case per million population both in the United States and internationally[1]

Duration of Infectiousness and disease

Symptomology

Latency

Asymptomatic Rates

Excretion Rates (see Exposure)

Immunity

Microbiology

An infectious agent composed of protein in a misfolded form

Environmental Survival

Recommended Dose Response Model

Dose response models for Prion
Beta-Poisson, α is 1.76 N50 is 1.04E+05
Betapoisson model.jpg





References

http://www.cdc.gov/ncidod/dvrd/prions/

  1. 1.0 1.1 1.2 Medscape
  2. John Collinge, Jerome Whitfi eld, Edward McKintosh, John Beck, Simon Mead, Dafydd J Thomas, Michael P Alpers. (2006) Kuru in the 21st century—an acquired human prion disease with very long incubation periods. Lancet. 367: 2068–74. Full Text