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Welcome to the CAMRA Microbial Risk Assessment Wiki (CAMRAwiki)
This website is dedicated to delivering the most up-to-date quantitative information and knowledge developed in the Quantitative Microbial Risk Assessment (QMRA) field. Our future goal is to become a central repository for QMRA knowledge and data. It is our intent to be a peer reviewed wiki where if users or visitors wish to add to our wiki they are welcome to submit their proposed addition to firstname.lastname@example.org for one of our experts to review for inclusion to the wiki.
Links on the left allow you to access pathogen information that CAMRA has compiled. Each pathogen has a Pathogen Safety Data Sheet (PSDS) that gives a brief overview of the hazard and its associated risks.
QMRA Evolution and Development
Quantitative microbial risk assessment (QMRA) is a framework and approach that brings information and data together with mathematical models to address the spread of microbial agents through environmental exposures and to characterize the nature of the adverse outcomes. Ultimately the goal in assessing risks is to develop and implement strategies that can monitor and control the risks (or safety) and allows one to respond to emerging diseases, outbreaks and emergencies that impact the safety of water, food, air, fomites and in general our outdoor and indoor environments.
Risk by it’s nature is probabilistic and thus relies developing quantitative information.
- The definition of RISK: chance*hazard*exposure*consequence
- Risk is the likelihood of identified hazards causing harm in exposed populations in a specified time frame including the severity of the consequences.
The traditional risk assessment process was seen as a four step process, Fig. 1 (NRC, Red Book, 1983) and was adopted for microbial hazards (Haas, Rose, Gerba, 1991).
- Hazard identification: The hazard identification is both identification of the microbial agent and the spectrum of human illness and disease associated with the specific microorganism.
- Dose response assessment: The dose response analysis provides a quantitative relationship between the likelihood of adverse effects and the level of microbial exposure. Without knowing how different levels of the stressor affect the individual a sizable portion of quantified risk estimate will not be possible. The dose response assessment phase is arguably the most important phase in the QMRA paradigm.
- Exposure assessment: The exposure assessment identifies affected population, determines the exposure pathways and environmental fate and transport, calculates the amount, frequency, length of time of exposure, and estimates dose or distribution of doses for an exposure.
- Risk characterization: The risk characterization Integrates dose-response analysis and exposure assessment to estimate the magnitude of risk, uncertainty and variability of the hazard.
Some other important developments of QMRA includes:
- QMRA Tools: A variety of QMRA tools begin as simplistic tools essentially established and tested Microsoft Excel spreadsheets. Some QMRA tools are being developed as standalone computer applications.
- Environmental Infection Transmission Systems (EITS): This work advances the conceptual framework for the science of environmental mediation of person to person transmitted infections by stochastic processes.
- Risk communication: The risk communication is an interactive process of exchange of information and opinion on risk among risk assessors, risk managers, stakeholders and general public.
More recently, according to the NRC’s Science and Decisions: Advancing Risk Assessment (NRC, 2008) the risk assessment-risk management paradigm should be integrated and include several phases.
The current QMRA framework shown in Figure 2 addresses the assessment-management integration and the need for monitoring to improve exposure assessment, characterization and management.
- Pathogen ID
- Clinical Outcomes
Exposure Assessment and Monitoring
- Fate and Transport
- Development of Surrogates for Field and Challenge Studies
- Protocols for Use of Surrogates
Dose Response Modeling
- Classical Models
- Advanced Dose Response Models
- Mechanistic and Physiologically Based Models
Risk Characterization, Management And Communication
- Understanding Best Use of Risk Assessment in Decision Making
- Assessment-Analysis Advances
- Infectious Disease Environmental Transmission Models
- Modeling How Communities Communicate
Haas, C.N., J.B.Rose and C.P., Gerba. 1999. Quantitative Microbial Risk Assessment.1st.Ed. John Wiley & Sons, Inc., New York.
NRC (National Research Council) 1983. Risk Assessment in the Federal Government: Managing the Process. Washington DC. National Academy Press
NRC (National Research Council) 2008. Science and Decisions: Advancing Risk Assessment. Washington DC. National Academy Press
Thank you for using CAMRAwiki.
This work was supported by EPA/DHS CAMRA Center Grant RD832362, but this wiki does not necessarily reflect the opinion of either the US Environmental Protection Agency or the US Department of Homeland Security.