Difference between revisions of "Listeria monocytogenes (Stillbirths): Dose Response Models"
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==='''General overview of ''Listeria monocytogenes'' '''=== | ==='''General overview of ''Listeria monocytogenes'' '''=== | ||
| − | ''Listeria monocytogenes'' is a gram-positive rod-shaped bacterium. It is the causative agent of listeriosis, a serious infection caused by eating food contaminated with the bacteria. The disease generally affects older adults, pregnant women, newborns, and adults with weakened immune systems. However, rarely, persons without these risk factors can also be affected ( | + | ''Listeria monocytogenes'' is a gram-positive rod-shaped bacterium. It is the causative agent of listeriosis, a serious infection caused by eating food contaminated with the bacteria. The disease generally affects older adults, pregnant women, newborns, and adults with weakened immune systems. However, rarely, persons without these risk factors can also be affected <ref name=Todar>Todar K (2012) Todar's Online Textbook of Bacteriology.[http://www.cdc.gov/listeria/ Todar]</ref> . |
| − | The overt form of the disease has mortality greater than 25 percent. The two main clinical manifestations are sepsis and meningitis. Meningitis is often complicated by encephalitis, a pathology that is unusual for bacterial infections | + | The overt form of the disease has mortality greater than 25 percent. The two main clinical manifestations are sepsis and meningitis. Meningitis is often complicated by encephalitis, a pathology that is unusual for bacterial infections <ref name=Todar></ref>. |
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==='''Summary Data'''=== | ==='''Summary Data'''=== | ||
| − | Smith et al.(2008) studied dose-response model for ''Listeria monocytogenes''- induced stillbirths in nonhuman primates | + | Smith et al.(2008) studied dose-response model for ''Listeria monocytogenes''- induced stillbirths in nonhuman primates <ref name=Smith></ref> and Williams et al ( 2007 and 2009) explored fetal mortality in guinea pigs after oral exposure <ref name=Williams2007></ref>. |
{{DRSummaryTableStart|agent=''Listeria monocytogenes''}} | {{DRSummaryTableStart|agent=''Listeria monocytogenes''}} | ||
| − | {{DRSummaryTablePreferredModeltworefs|expID= 289,290 |refer1=Smith | + | {{DRSummaryTablePreferredModeltworefs|expID= 289,290 |refer1=Smith|reference1=Smith, M. A., K. Takeuchi, et al. (2008). "Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates." Infection and Immunity 76(2): 726-731|refer2=Williams2007|reference2=Williams, D., E. A. Irvin, et al. (2007)."Dose-Response of Listeria monocytogenes after Oral Exposure in Pregnant Guinea Pigs." Journal of Food Protection 70(5): 1122-1128|host=pooled |agentStrain= |route= oral |nDoses= 13 |doseUnits= CFU |response= stillbirths |bestFitModel=beta-Poisson|parameters=α = 4.22E-02 , N<sub>50</sub> = 1.78E+09 |N50= 1.78E+09 }} |
| − | {{DRSummaryTableNonpreferredModel|expID= 289 |refer=Smith | + | {{DRSummaryTableNonpreferredModel|expID= 289 |refer=Smith|reference=Smith, M. A., K. Takeuchi, et al. (2008). "Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates." Infection and Immunity 76(2): 726-731|host= rhesus monkeys |agentStrain= |route= oral |nDoses= 8 |doseUnits= CFU |response= stillbirths |bestFitModel=beta-Poisson|parameters=α = 4E-02 , N<sub>50</sub> = 8.26E+08 |N50= 8.26E+08 }} |
| − | {{DRSummaryTableNonpreferredModel|expID= 290 |refer= | + | {{DRSummaryTableNonpreferredModel|expID= 290 |refer=Williams2007|reference=Williams, D., E. A. Irvin, et al. (2007)."Dose-Response of Listeria monocytogenes after Oral Exposure in Pregnant Guinea Pigs." Journal of Food Protection 70(5): 1122-1128|host= guinea pig |agentStrain= |route= oral |nDoses= 5 |doseUnits= CFU |response= fetal mortality |bestFitModel=beta-Poisson|parameters=α = 9.36E-02 , N<sub>50</sub> = 4.67E+07 |N50= 4.67E+07 }} |
{{DRSummaryTableEnd}} | {{DRSummaryTableEnd}} | ||
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==='''Optimization Output for experiment 289'''=== | ==='''Optimization Output for experiment 289'''=== | ||
| − | {{DRExperimentDataTable8|title=Rhesus monkey/''Listeria monocytogenes''|refer=Smith | + | {{DRExperimentDataTable8|title=Rhesus monkey/''Listeria monocytogenes''|refer=Smith|reference=Smith, M. A., K. Takeuchi, et al. (2008). "Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates." Infection and Immunity 76(2): 726-731|host= rhesus monkeys|pos=Stillbirths|neg=Not stillbirths|d1=316|p1=0|n1=1|t1=1|d2=1580|p2=2|n2=6|t2=8|d3=2E+04|p3=0|n3=3|t3=3|d4=126000|p4=1|n4=4|t4=5|d5=1580000|p5=2|n5=4|t5=6|d6=1.26E+07|p6=2|n6=3|t6=5|d7=1.26E+08|p7=2|n7=2|t7=4|d8=3.98E+10|p8=1|n8=0|t8=1}} |
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| − | {{DRExperimentDataTable5|title=Guinea pig/''Listeria monocytogenes''|refer= | + | {{DRExperimentDataTable5|title=Guinea pig/''Listeria monocytogenes''|refer=Williams2007|reference=Williams, D., E. A. Irvin, et al. (2007)."Dose-Response of Listeria monocytogenes after Oral Exposure in Pregnant Guinea Pigs." Journal of Food Protection 70(5): 1122-1128|host= guinea pig |pos=Fetal mortality|neg=Not fetal mortality|d1=1E+04|p1=0|n1=4|t1=4|d2=1E+05|p2=2|n2=9|t2=11|d3=1E+06|p3=2|n3=7|t3=9|d4=1E+07|p4=3|n4=6|t4=9|d5=1E+08|p5=3|n5=1|t5=4}} |
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<references /> | <references /> | ||
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Williams D, Castleman J, et al. (2009) Risk of Fetal Mortality After Exposure to Listeria monocytogenes Based on Dose-Response Data from Pregnant Guinea Pigs and Primates. Risk Analysis 29(11): 1495-1505. | Williams D, Castleman J, et al. (2009) Risk of Fetal Mortality After Exposure to Listeria monocytogenes Based on Dose-Response Data from Pregnant Guinea Pigs and Primates. Risk Analysis 29(11): 1495-1505. | ||
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[[Category:Completed Dose Response Models: Bacteria]][[Category:Dose Response Model]][[Category:Pseudomonas aeruginosa]] | [[Category:Completed Dose Response Models: Bacteria]][[Category:Dose Response Model]][[Category:Pseudomonas aeruginosa]] | ||
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Revision as of 03:46, 12 October 2012
Contents
Listeria monocytogenes (Stillbirths in animals)
General overview of Listeria monocytogenes
Listeria monocytogenes is a gram-positive rod-shaped bacterium. It is the causative agent of listeriosis, a serious infection caused by eating food contaminated with the bacteria. The disease generally affects older adults, pregnant women, newborns, and adults with weakened immune systems. However, rarely, persons without these risk factors can also be affected [1] .
The overt form of the disease has mortality greater than 25 percent. The two main clinical manifestations are sepsis and meningitis. Meningitis is often complicated by encephalitis, a pathology that is unusual for bacterial infections [1].
Summary Data
Smith et al.(2008) studied dose-response model for Listeria monocytogenes- induced stillbirths in nonhuman primates [2] and Williams et al ( 2007 and 2009) explored fetal mortality in guinea pigs after oral exposure [3].
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Optimization Output for pooled data (experiment 289 and 290)
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Optimization Output for experiment 289
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Optimization Output for experiment 290
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Summary
The risk of fetal mortality in nonhuman primate ( rhesus monkeys) and guinea pigs statistically same and hence the pooled model with larger data points is recommended model.
References
- ↑ 1.0 1.1 Todar K (2012) Todar's Online Textbook of Bacteriology.Todar
- ↑ 2.0 2.1 2.2 2.3 Smith, M. A., K. Takeuchi, et al. (2008). "Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates." Infection and Immunity 76(2): 726-731
- ↑ 3.0 3.1 3.2 3.3 Williams, D., E. A. Irvin, et al. (2007)."Dose-Response of Listeria monocytogenes after Oral Exposure in Pregnant Guinea Pigs." Journal of Food Protection 70(5): 1122-1128
Williams D, Castleman J, et al. (2009) Risk of Fetal Mortality After Exposure to Listeria monocytogenes Based on Dose-Response Data from Pregnant Guinea Pigs and Primates. Risk Analysis 29(11): 1495-1505.
