Difference between revisions of "Listeria monocytogenes (Stillbirths): Dose Response Models"
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{{DRSummaryTableNonpreferredModel|expID= 290 |refer=Williams, Irvin et al. 2007|reference=Williams, D., E. A. Irvin, et al. (2007)."Dose-Response of Listeria monocytogenes after Oral Exposure in Pregnant Guinea Pigs." Journal of Food Protection 70(5): 1122-1128|host= guinea pig |agentStrain= |route= oral |nDoses= 5 |doseUnits= CFU |response= fetal mortality |bestFitModel=beta-Poisson|parameters= α = 9.36E-02 , N<sub>50</sub> = 4.67E+07 |N50= 4.67E+07 }} | {{DRSummaryTableNonpreferredModel|expID= 290 |refer=Williams, Irvin et al. 2007|reference=Williams, D., E. A. Irvin, et al. (2007)."Dose-Response of Listeria monocytogenes after Oral Exposure in Pregnant Guinea Pigs." Journal of Food Protection 70(5): 1122-1128|host= guinea pig |agentStrain= |route= oral |nDoses= 5 |doseUnits= CFU |response= fetal mortality |bestFitModel=beta-Poisson|parameters= α = 9.36E-02 , N<sub>50</sub> = 4.67E+07 |N50= 4.67E+07 }} | ||
{{DRSummaryTablePreferredModel|expID= 289,290 |refer=Smith, Takeuchi et al. 2008 and Williams, Irvin et al. 2007|reference=Smith, M. A., K. Takeuchi, et al. (2008). "Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates." Infection and Immunity 76(2): 726-731 and Williams, D., E. A. Irvin, et al. (2007)."Dose-Response of Listeria monocytogenes after Oral Exposure in Pregnant Guinea Pigs." Journal of Food Protection 70(5): 1122-1128|host=pooled |agentStrain= |route= oral |nDoses= 13 |doseUnits= CFU |response= stillbirths |bestFitModel=beta-Poisson|parameters= α = 4.22E-02 , N<sub>50</sub> = 1.78E+09 |N50= 1.78E+09 }} | {{DRSummaryTablePreferredModel|expID= 289,290 |refer=Smith, Takeuchi et al. 2008 and Williams, Irvin et al. 2007|reference=Smith, M. A., K. Takeuchi, et al. (2008). "Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates." Infection and Immunity 76(2): 726-731 and Williams, D., E. A. Irvin, et al. (2007)."Dose-Response of Listeria monocytogenes after Oral Exposure in Pregnant Guinea Pigs." Journal of Food Protection 70(5): 1122-1128|host=pooled |agentStrain= |route= oral |nDoses= 13 |doseUnits= CFU |response= stillbirths |bestFitModel=beta-Poisson|parameters= α = 4.22E-02 , N<sub>50</sub> = 1.78E+09 |N50= 1.78E+09 }} | ||
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Revision as of 21:01, 4 September 2012
Contents
Listeria monocytogenes (Stillbirths in animals)
General overview of Listeria monocytogenes
Listeria monocytogenes is a gram-positive rod-shaped bacterium. It is the causative agent of listeriosis, a serious infection caused by eating food contaminated with the bacteria. The disease generally affects older adults, pregnant women, newborns, and adults with weakened immune systems. However, rarely, persons without these risk factors can also be affected (CDC 2012; Todar 2012).
The overt form of the disease has mortality greater than 25 percent. The two main clinical manifestations are sepsis and meningitis. Meningitis is often complicated by encephalitis, a pathology that is unusual for bacterial infections (Todar 2012).
Summary Data
Smith et al.(2008) studied dose-response model for Listeria monocytogenes- induced stillbirths in nonhuman primates (Smith, Takeuchi et al. 2008) and Williams et al ( 2007 and 2009) explored fetal mortality in guinea pigs after oral exposure (Williams, Irvin et al. 2007; Williams, Castleman et al. 2009).
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Optimization Output for experiment 289
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Optimization Output for experiment 290
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Optimization Output for pooled data (experiment 289 and 290)
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Summary
The risk of fetal mortality in nonhuman primate ( rhesus monkeys) and guinea pigs statistically same and hence the pooled model with larger data points is recommended model.
References
- ↑ Smith, M. A., K. Takeuchi, et al. (2008). "Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates." Infection and Immunity 76(2): 726-731
- ↑ Williams, D., E. A. Irvin, et al. (2007)."Dose-Response of Listeria monocytogenes after Oral Exposure in Pregnant Guinea Pigs." Journal of Food Protection 70(5): 1122-1128
- ↑ Smith, M. A., K. Takeuchi, et al. (2008). "Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates." Infection and Immunity 76(2): 726-731 and Williams, D., E. A. Irvin, et al. (2007)."Dose-Response of Listeria monocytogenes after Oral Exposure in Pregnant Guinea Pigs." Journal of Food Protection 70(5): 1122-1128
- ↑ 4.0 4.1 4.2 Smith, M. A., K. Takeuchi, et al. (2008)."Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates." Infection and Immunity 76(2): 726-731 Cite error: Invalid
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CDC (2012) "Listeria (Listeriosis)."
Smith MA, Takeuchi K, et al. (2008) Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates. Infection and Immunity 76(2): 726-731.
Todar K (2012) Todar's Online Textbook of Bacteriology.
Williams D, Castleman J, et al. (2009) Risk of Fetal Mortality After Exposure to Listeria monocytogenes Based on Dose-Response Data from Pregnant Guinea Pigs and Primates. Risk Analysis 29(11): 1495-1505.
Williams D, Irvin EA, et al. (2007) Dose-Response of Listeria monocytogenes after Oral Exposure in Pregnant Guinea Pigs. Journal of Food Protection 70(5): 1122-1128.