Difference between revisions of "Listeria monocytogenes (Infection): Dose Response Models"
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==='''Summary Data'''=== | ==='''Summary Data'''=== | ||
| − | Golnazarian et al.(1989) also compared infectious dose in normal and compromised C57BL/6J mice with pathogens (strain F5817) via oral route and responses were recorded as death and infection separately (Golnazarian, Donnelly et al. 1989). Audurier et al.(1980) conducted an experiment on Swiss female mice (OF1) via oral route and infection was observed after 28 days of inoculation.The dose-response analysis of both cases were published by Haas, Thayyar-Madabusi in 1999 (Audurier, Pardon et al. 1980; Haas, Thayyar- Madabusi et al. 1999). | + | Golnazarian et al.(1989)<ref name=Golnazarian></ref> also compared infectious dose in normal and compromised C57BL/6J mice with pathogens (strain F5817) via oral route and responses were recorded as death and infection separately (Golnazarian, Donnelly et al. 1989). Audurier et al.(1980) conducted an experiment on Swiss female mice (OF1) via oral route and infection was observed after 28 days of inoculation.The dose-response analysis of both cases were published by Haas, Thayyar-Madabusi in 1999 (Audurier, Pardon et al. 1980; Haas, Thayyar- Madabusi et al. 1999). |
{{DRSummaryTableStart|agent=''Listeria monocytogenes''}} | {{DRSummaryTableStart|agent=''Listeria monocytogenes''}} | ||
| − | {{DRSummaryTablePreferredModel|expID= 292,295 Pooled |refer=Golnazarian | + | {{DRSummaryTablePreferredModel|expID= 292,295 Pooled |refer=Golnazarian|reference=Golnazarian, C. A., C. W. Donnelly, et al. (1989). "Comparison of infectious dose of Listeria monocytogenes F5817 as determined for normal versus compromised C57B1/6J mice." Journal of food protection 52(10): 696-701.|host= C57Bl/6J mice |agentStrain= F5817 |route= oral |nDoses= 10 |doseUnits= CFU |response= infection |bestFitModel=beta-Poisson|parameters=α = 2.53E-01 , N<sub>50</sub> = 2.77E+02 |N50= 2.77E+02 }} |
| − | {{DRSummaryTableNonpreferredModel|expID= 292 |refer=Golnazarian | + | {{DRSummaryTableNonpreferredModel|expID= 292 |refer=Golnazarian|reference=Golnazarian, C. A., C. W. Donnelly, et al. (1989). "Comparison of infectious dose of Listeria monocytogenes F5817 as determined for normal versus compromised C57B1/6J mice." Journal of food protection 52(10): 696-701.|host= C57Bl/6J mice |agentStrain=F5817|route= oral |nDoses= 6 |doseUnits= CFU |response= infection |bestFitModel=beta-Poisson|parameters=α = 6.95E-01 , N<sub>50</sub> = 3.39E+03 |N50= 3.39E+03 }} |
| − | {{DRSummaryTableNonpreferredModel|expID=295 |refer=Golnazarian | + | {{DRSummaryTableNonpreferredModel|expID=295 |refer=Golnazarian|reference=Golnazarian, C. A., C. W. Donnelly, et al. (1989). "Comparison of infectious dose of Listeria monocytogenes F5817 as determined for normal versus compromised C57B1/6J mice." Journal of food protection 52(10): 696-701.|host= C57Bl/6J mice|agentStrain= F5817 |route= oral |nDoses= 4 |doseUnits= CFU |response= infection |bestFitModel=beta-Poisson|parameters=α = 1.2E-01 , N<sub>50</sub> = 1.16E+03 |N50= 1.16E+03 }} |
{{DRSummaryTableNonpreferredModel|expID= 296 |refer=Audurier, Pardon et al. 1980|reference=Audurier, A., P. Pardon, et al. (1980). "Experimental infection of mice with Listeria monocytogenes and L. innocua." Annales de microbiologie 131B(1): 47-57.|host= OF1 mice |agentStrain= strain 10401 |route= oral |nDoses= 5 |doseUnits= CFU |response= infection |bestFitModel=beta-Poisson|parameters=α = 1.72E-01 , N<sub>50</sub> = 2.06E+06 |N50= 2.06E+06 }} | {{DRSummaryTableNonpreferredModel|expID= 296 |refer=Audurier, Pardon et al. 1980|reference=Audurier, A., P. Pardon, et al. (1980). "Experimental infection of mice with Listeria monocytogenes and L. innocua." Annales de microbiologie 131B(1): 47-57.|host= OF1 mice |agentStrain= strain 10401 |route= oral |nDoses= 5 |doseUnits= CFU |response= infection |bestFitModel=beta-Poisson|parameters=α = 1.72E-01 , N<sub>50</sub> = 2.06E+06 |N50= 2.06E+06 }} | ||
{{DRSummaryTableEnd}} | {{DRSummaryTableEnd}} | ||
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| − | {{DRExperimentDataTable10|title=Pooled C57Bl/6J mice/''Listeria monocytogenes''|refer=Golnazarian | + | {{DRExperimentDataTable10|title=Pooled C57Bl/6J mice/''Listeria monocytogenes''|refer=Golnazarian|reference=Golnazarian, C. A., C. W. Donnelly, et al. (1989). "Comparison of infectious dose of Listeria monocytogenes F5817 as determined for normal versus compromised C57B1/6J mice." Journal of food protection 52(10): 696-701|pos=Infected|neg=Non-infected|d1=2|p1=0|n1=6|t1=6|d2=5|p2=1|n2=5|t2=6|d3=110|p3=2|n3=4|t3=6|d4=5500|p4=7|n4=3|t4=10|d5=32400|p5=7|n5=3|t5=10|d6=39000|p6=4|n6=2|t6=6|d7=55000|p7=9|n7=1|t7=10|d8=251000|p8=10|n8=0|t8=10|d9=550000|p9=10|n9=0|t9=10|d10=2820000|p10=10|n10=0|t10=10}} |
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| − | {{DRExperimentDataTable6|title=C57Bl/6J mice/''Listeria monocytogenes''|refer=Golnazarian | + | {{DRExperimentDataTable6|title=C57Bl/6J mice/''Listeria monocytogenes''|refer=Golnazarian|reference=Golnazarian, C. A., C. W. Donnelly, et al. (1989). "Comparison of infectious dose of Listeria monocytogenes F5817 as determined for normal versus compromised C57B1/6J mice." Journal of food protection 52(10): 696-701|pos=Infected|neg=Non-infected|d1=5500|p1=7|n1=3|t1=10|d2=32400|p2=7|n2=3|t2=10|d3=55000|p3=9|n3=1|t3=10|d4=251000|p4=10|n4=0|t4=10|d5=550000|p5=10|n5=0|t5=10|d6=2820000|p6=10|n6=0|t6=10}} |
| Line 68: | Line 68: | ||
| − | {{DRExperimentDataTable4|title=C57Bl/6J mice/''Listeria monocytogenes''|refer=Golnazarian | + | {{DRExperimentDataTable4|title=C57Bl/6J mice/''Listeria monocytogenes''|refer=Golnazarian|reference=Golnazarian, C. A., C. W. Donnelly, et al. (1989). "Comparison of infectious dose of Listeria monocytogenes F5817 as determined for normal versus compromised C57B1/6J mice." Journal of food protection 52(10): 696-701|pos=Infected|neg=Non-infected|d1=2|p1=0|n1=6|t1=6|d2=5|p2=1|n2=5|t2=6|d3=110|p3=2|n3=4|t3=6|d4=39000|p4=4|n4=2|t4=6}} |
Revision as of 03:02, 12 October 2012
Contents
Listeria monocytogenes (Infection)
General overview of Listeria monocytogenes
Listeria monocytogenes is a gram-positive rod-shaped bacterium. It is the causative agent of listeriosis, a serious infection caused by eating food contaminated with the bacteria. The disease generally affects older adults, pregnant women, newborns, and adults with weakened immune systems. However, rarely, persons without these risk factors can also be affected [1] [2]
The overt form of the disease has mortality greater than 25 percent. The two main clinical manifestations are sepsis and meningitis. Meningitis is often complicated by encephalitis, a pathology that is unusual for bacterial infections [2].
Summary Data
Golnazarian et al.(1989)[3] also compared infectious dose in normal and compromised C57BL/6J mice with pathogens (strain F5817) via oral route and responses were recorded as death and infection separately (Golnazarian, Donnelly et al. 1989). Audurier et al.(1980) conducted an experiment on Swiss female mice (OF1) via oral route and infection was observed after 28 days of inoculation.The dose-response analysis of both cases were published by Haas, Thayyar-Madabusi in 1999 (Audurier, Pardon et al. 1980; Haas, Thayyar- Madabusi et al. 1999).
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Optimization Output for experiment 292 and 295 (Pooling)
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Optimization Output for experiment 292
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Optimization Output for experiment 295
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Optimization Output for experiment 296
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Summary
As the two data set of C57 Bl/6 J mice inoculated with L. monocytogenes (Golnazarian, Donnelly et al. 1989) could be pooled. The pooled model is recommended to use as recommended model. However, according to Haas, Thayyar-Madabusi et al.(1999), the dose-response model of the experiment number 296 (Audurier, Pardon et al. 1980) showed consistence result to some reported outbreaks.
References
- ↑ CDC
- ↑ 2.0 2.1 Todar
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Golnazarian, C. A., C. W. Donnelly, et al. (1989). "Comparison of infectious dose of Listeria monocytogenes F5817 as determined for normal versus compromised C57B1/6J mice." Journal of food protection 52(10): 696-701. Cite error: Invalid
<ref>tag; name "Golnazarian" defined multiple times with different content Cite error: Invalid<ref>tag; name "Golnazarian" defined multiple times with different content Cite error: Invalid<ref>tag; name "Golnazarian" defined multiple times with different content - ↑ 4.0 4.1 Audurier, A., P. Pardon, et al. (1980). "Experimental infection of mice with Listeria monocytogenes and L. innocua." Annales de microbiologie 131B(1): 47-57.
Audurier A, Pardon P, et al. (1980) Experimental infection of mice with Listeria monocytogenes and L. innocua. Annales de microbiologie 131B(1): 47-57.
CDC (2012) "Listeria (Listeriosis)"
Golnazarian CA, Donnelly CW, et al. (1989) Comparison of infectious dose of Listeria monocytogenes F5817 as determined for normal versus compromised C57B1/6J mice. Journal of food protection 52(10): 696-701.
Haas CN, Thayyar-Madabusi A, et al. (1999) Development and Validation of Dose-Response Relationship for Listeria monocytogenes. Quantitative Microbiology 1(1): 89-102.
Smith MA, Takeuchi K, et al. (2008) Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates. Infection and Immunity 76(2): 726-731.
Todar K (2012) Todar's Online Textbook of Bacteriology.
