Feeding Experiment for Escherichia coli

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Experiment data

Table 5.2. Escherichia coli (EIEC 4608) in the human oral data
Dose(Cells)
Dead
Survived
Total
1 (104)
0
5
5
1 (106)
0
5
5
1 (108)
5
3
8
DuPont et al. (1971)
Table 5.5 Escherichia coli (EIEC 1624) in the Human oral data
Dose(Cells)
Dead
Survived
Total
1 (104)
0
5
5
1 (106)
1
8
9
1 (108)
3
2
5
DuPont et al. (1971)
Table 5.8 Escherichia coli (ETEC O55 (in paper as “type 55, B5”)) in the human oral data
Dose(Cells)
Dead
Survived
Total
1.4 (108)
6
2
8
1.7 (109)
5
2
7
5.3 (109)
6
2
8
1.6 (1010)
7
1
8
June et al. (1953)


Table 5.11 Escherichia coli (ETEC O111 (in paper as “E. coli 111, B4”)) in the human oral data
Dose(Cells)
Dead
Survived
Total
7 (106)
7
4
11
5.3 (108)
8
4
12
6.5 (109)
11
0
11
9 (109)
12
0
12
Ferguson et al. (1952)
Table 5.14 Escherichia coli (ETEC 214-4 (ST)) in the human oral data
Dose(Cells)
Dead
Survived
Total
1 (106)
0
4
4
1 (108)
3
2
5
1 (1010)
4
1
5
Levine et al. (1977)
Table 5.17 Escherichia coli (EPEC B171-8 (serotype O11:NM)) in the human oral data
Dose(CFU)
Dead
Survived
Total
5 (108)
3
2
5
2.5 (109)
6
0
6
2 (1010)
2
0
2
Bieber et al. (1998)
Table 5.20 Escherichia coli (EIEC 1624) in the human oral data
Dose(Cells)
Dead
Survived
Total
1 (104)
0
5
5
1 (106)
5
4
9
1 (108)
3
2
5
DuPont et al. (1971)
Table 5.23 E. coli disease (ETEC, EPEC, EIEC) in the human oral data
Dose(CFU)
Dead
Survived
Total
1 (104)
0
5
5
1 (104)
0
5
5
1 (106)
0
5
5
1 (106)
1
8
9
1 (108)
5
3
8
1 (108)
1
4
5
1 (108)
3
2
5
1 (108)
2
3
5
1.4 (108)
6
2
8
2.7 (108)
9
7
16
1.7 (109)
5
2
7
5.3 (109)
6
2
8
1 (1010)
4
1
5
1 (1010)
3
2
5
1.6 (1010)
7
1
8
DuPont et al. (1971), June et al. (1953), Graham et al. (1983)
Table 5.26 EPEC disease in the human oral data
Dose(CFU)
Dead
Survived
Total
1 (106)
0
4
4
1 (106)
1
4
5
1 (108)
1
4
5
5 (108)
3
2
5
2.5 (109)
6
0
6
1 (1010)
3
2
5
1 (1010)
5
0
5
2 (1010)
2
0
2
DuPont et al. (1971), June et al. (1953), Graham et al. (1983)
Table 5.29 EPEC disease in the human oral data
Dose(CFU)
Dead
Survived
Total
1 (106)
3
3
6
1 (107)
6
9
15
1 (108)
6
1
7
1 (108)
7
4
11
1 (108)
7
5
12
1 (108)
9
3
12
1 (108)
6
3
9
1 (108)
4
2
6
1 (108)
3
1
4
1 (108)
4
0
4
2.7 (108)
9
7
16
5 (108)
19
8
27
1 (109)
5
3
8
1 (109)
7
1
8
1 (109)
5
5
10
1 (1010)
8
0
8
1 (1010)
5
4
9
1 (1010)
9
3
12
1 (1010)
9
5
14
Coster et al. (2007), Graham et al. (1983), Levine et al. (1979), Levine et al. (1980), Clements et al. (1981), Levine et al. (1982)
Table 5.32 ETEC disease, unbuffered, in the human oral data
Dose(CFU)
Dead
Survived
Total
1 (106)
0
4
4
1 (108)
1
4
5
1 (108)
2
3
5
1 (108)
3
2
5
1.4 (108)
6
2
8
1.7 (109)
5
2
7
5.3 (109)
6
2
8
1 (1010)
4
1
5
1 (1010)
3
2
5
1 (1010)
4
1
5
1.6 (1010)
7
1
8
DuPont et al. (1971), June et al. (1953), Levine et al. (1977)
Table 5.35 ETEC infection, unbuffered, in the human oral data
Dose(CFU)
Dead
Survived
Total
1 (106)
0
4
4
1 (106)
1
4
5
1 (108)
1
4
5
5 (108)
3
2
5
2.5 (109)
6
0
6
1 (1010)
9
1
10
1 (1010)
9
5
14
1 (1010)
3
2
5
1 (1010)
5
0
5
2 (1010)
2
0
2
2.3 (1010)
14
5
19
Tacket et al. (2000), Donnenberg et al. (1998), Bieber et al. (1998), Levine et al. (1978)
Table 5.38 EPEC, infection, buffered, in the human oral data
Dose(CFU)
Dead
Survived
Total
1 (106)
3
1
4
1 (106)
5
0
5
1 (106)
4
1
5
1 (108)
5
0
5
1 (108)
5
0
5
9 (108)
8
0
8
1 (1010)
10
0
10
1 (1010)
9
0
9
1 (1010)
14
0
14
1 (1010)
5
0
5
1 (1010)
5
0
5
1 (1010)
5
0
5
2.3 (1010)
19
0
19
Tacket et al. (2000), Donnenberg et al. (1993), Levine et al. (1978)
Table 5.41 EIEC disease, unbuffered, in the human oral data
Dose(Cells)
Dead
Survived
Total
1 (104)
0
5
5
1 (104)
0
5
5
1 (106)
0
5
5
1 (106)
1
8
9
1 (108)
5
3
8
1 (108)
3
2
5
DuPont et al. (1971)


References

Bieber, D. et al., 1998. Type IV pili, transient bacterial aggregates, and virulence of enteropathogenic Escherichia coli. Science (New York, N.Y.), 280(5372), pp.2114-2118. Full text  

Clements, M.L. et al., 1981. Lactobacillus prophylaxis for diarrhea due to enterotoxigenic Escherichia coli. Antimicrobial Agents and Chemotherapy, 20(1), pp.104-108. Full text  

Coster, T.S. et al., 2007. Immune response, ciprofloxacin activity, and gender differences after human experimental challenge by two strains of enterotoxigenic Escherichia coli. Infection and Immunity, 75(1), pp.252-259. Full text  

DuPont, H.L. et al., 1971. Pathogenesis of Escherichia coli diarrhea. The New England Journal of Medicine, 285(1), pp.1-9. Abstract  

Donnenberg, M.S. et al., 1993. Role of the eaeA gene in experimental enteropathogenic Escherichia coli infection. The Journal of Clinical Investigation, 92(3), pp.1412-1417. Full text  

Graham, D.Y., Estes, M.K. & Gentry, L.O., 1983. Double-blind comparison of bismuth subsalicylate and placebo in the prevention and treatment of enterotoxigenic Escherichia coli-induced diarrhea in volunteers. Gastroenterology, 85(5), pp.1017-1022. Abstract  

June, R.C., Ferguson, W.W. & Worfel, M.T., 1953. Experiments in feeding adult volunteers with Escherichia coli 55, B5, a coliform organism associated with infant diarrhea. American Journal of Hygiene, 57(2), pp.222-236. Full text  

Ferguson, W.W. & June, R.C., 1952. Experiments on feeding adult volunteers with Escherichia coli 111, B4, a coliform organism associated with infant diarrhea. American Journal of Hygiene, 55(2), pp.155-169. Full text 

Levine, M.M. et al., 1978. Escherichia coli strains that cause diarrhoea but do not produce heat-labile or heat-stable enterotoxins and are non-invasive. Lancet, 1(8074), pp.1119-1122. Abstract  

Levine, M.M. et al., 1977. Diarrhea caused by Escherichia coli that produce only heat-stable enterotoxin. Infection and Immunity, 17(1), pp.78-82. Full text  

Levine, M.M. et al., 1982. Reactogenicity, immunogenicity and efficacy studies of Escherichia coli type-1 somatic pili parenteral vaccine in man. Scandinavian Journal of Infectious Diseases, Suppl. 33, pp.83-95. Abstract  

Levine, M.M. et al., 1980. Lack of person-to-person transmission of enterotoxigenic Escherichia coli despite close contact. American Journal of Epidemiology, 111(3), pp.347-355. Full text  

Tacket, C.O. et al., 2000. Role of EspB in experimental human enteropathogenic Escherichia coli infection. Infection and Immunity, 68(6), pp.3689-3695. Full text