Difference between revisions of "Enteroviruses: Dose Response Models"
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| − | | Experiment number || Reference || Host type/pathogen strain || Route/number of doses || Dose units || Response || Best-fit model || | + | | Experiment number || Reference || Host type/pathogen strain || Route/number of doses || Dose units || Response || Best-fit model || Optimized parameters || LD<sub>50</sub> |
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| − | | 1 || Cliver, 1981 || pigs/ Porcine enterovirus type 3 || oral/3 || pfu || infection || Beta-Poisson || k= | + | | 1 || Cliver, 1981 || pigs/ Porcine enterovirus type 3 || oral/3 || pfu || infection || Beta-Poisson || k=2.96E-04 || 2340.15 |
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| − | | 2 || Cliver, 1981 || pigs/ Porcine enterovirus type 7 || oral/3 || pfu || infection || Beta-Poisson || k= | + | | 2 || Cliver, 1981 || pigs/ Porcine enterovirus type 7 || oral/3 || pfu || infection || Beta-Poisson || k=3.75E-03 || 185.10 |
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==='''Optimized Models and Uncertainty and Fitting Analyses'''=== | ==='''Optimized Models and Uncertainty and Fitting Analyses'''=== | ||
Revision as of 15:25, 7 July 2011
Contents
Enteroviruses
General overview
Enterovirus, a kind of small (30 nm), nonenveloped, single-stranded RNA viruses, belongs to the family Picornaviridae. While most of the enterovirus infections are relatively mild and result in complete recovery of the patient, they can also cause severe and fatal diseases such as meningitis, encephalitis, myocarditis, neonatal sepsis, and polio. Infection occurs mainly via fecal-oral transmission and less commonly by respiratory droplets. While no known non-human reservoirs have been identified, water-borne, foodborne, and blood-borne transmissions have been reported (Stalkup and Chilukuri 2002).
Summary Data
Cliver (1981) challenged pigs with Porcine enterovirus type 3 and 7 via oral exposure route.
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The data from different experiments were not able to be statistically pooled.
Optimized Models and Uncertainty and Fitting Analyses
Output for experiment 1.
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_Enterovirus_ExpHist.png)
_Enterovirus_ExpModel.png)
Fig 20.1. Models plot for experiment 1. (a) Uncertainty plot of exponential model; (b) Plot of exponential model with upper and lower 95% and 99% confidence.
Output for experiment 2.
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_Enterovirus_ExpHist.png)
_Enterovirus_ExpModel.png)
Fig 20.2. Models plot for experiment 2. (a) Uncertainty plot of exponential model; (b) Plot of exponential model with upper and lower 95% and 99% confidence.
Summary
The different LD50 for these two experiments indicates various virulence between pathogen strains.
References
Cliver, D. O. (1981). "Experimental infection by waterborne enteroviruses." Journal of Food Protection 44: 861-865.
Stalkup, J. R. and S. Chilukuri (2002). "Enterovirus infections: a review of clinical presentation, diagnosis, and treatment." Dermatologic clinics 20(2): 217-223.
