Difference between revisions of "Charteritest"

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(Created page with "__NOTOC__ Please click on the tab headings to navigate betweeen tabs.| We generally recommend a single dose response model, and we justify the decision in terms of {{#switchta...")
 
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Please click on the tab headings to navigate betweeen tabs.| We generally recommend a single dose response model, and we justify the decision in terms of {{#switchtablink:Criteria for Model Selection|these criteria}}. This decision is somewhat subjective, since dose response datasets seldom meet all of these criteria. If all available models are unsatisfactory, we choose a single model to ‘recommend with reservations’. Our recommended model will seldom (if ever) be the best model for all applications. The user should carefully choose the model that is most appropriate for their particular problem.
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|?RDR Best Fit=Best Fit Model
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{{#ask:[[[Recommended DR Model::<q>[[Category:Bacterium]]</q>]]|format = template|introtemplate =DRallmodelsTableStart|outrotemplate =DRallpreferredModelsTableEnd|mainlabel =show|headers =hide|template=DRallmodelsROW|?RDR Best Fit=Best Fit Model|?RDR Parameter=Parameter|?RDR N50=N50|?RDR Host=Host |?RDR Strain=Agent Strain |?RDR Route=Route|?RDR Dose=Dose|?RDR Unit=Dose Unit|?RDR Response=Response|?RDR Reference=Reference|limit=500}}
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{{#ask:[[[Recommended DR Model::<q>[[Category:Virus]]</q>]]|format = template|introtemplate =DRallmodelsTableStart|outrotemplate =DRallpreferredModelsTableEnd|mainlabel =show|headers =hide|template=DRallmodelsROW|?RDR Best Fit=Best Fit Model|?RDR Parameter=Parameter|?RDR N50=N50|?RDR Host=Host |?RDR Strain=Agent Strain |?RDR Route=Route|?RDR Dose=Dose|?RDR Unit=Dose Unit|?RDR Response=Response|?RDR Reference=Reference|limit=500}}
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{{#ask:[[[Recommended DR Model::<q>[[Category:Protozoan]]</q>]]|format = template|introtemplate =DRallmodelsTableStart|outrotemplate =DRallpreferredModelsTableEnd|mainlabel =show|headers =hide|template=DRallmodelsROW|?RDR Best Fit=Best Fit Model|?RDR Parameter=Parameter|?RDR N50=N50|?RDR Host=Host |?RDR Strain=Agent Strain |?RDR Route=Route|?RDR Dose=Dose|?RDR Unit=Dose Unit|?RDR Response=Response|?RDR Reference=Reference|limit=500}}
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|searchlabel=... further results
 
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{{#ask:[[[Recommended DR Model::<q>[[Category:Prion]]</q>]]|format = template|introtemplate =DRallmodelsTableStart|outrotemplate =DRallpreferredModelsTableEnd|mainlabel =show|headers =hide|template=DRallmodelsROW|?RDR Best Fit=Best Fit Model|?RDR Parameter=Parameter|?RDR N50=N50|?RDR Host=Host |?RDR Strain=Agent Strain |?RDR Route=Route|?RDR Dose=Dose|?RDR Unit=Dose Unit|?RDR Response=Response|?RDR Reference=Reference|limit=500}}
 
 
 
= Criteria for Model Selection =
 
 
 
We prefer dose response models with the following criteria, in rough order of importance:
 
 
 
#Statistically acceptable fit (fail to reject goodness of fit, p > 0.05)
 
#Human subjects, or animal models that mimic human pathophysiology well
 
#Infection as the response, rather than disease, symptoms, or death
 
#Exposure route similar/identical to the exposure route of natural infection
 
#Pathogen strain is similar to strains causing natural infection
 
#Pooled model using data from 2 or more experiments, provided the data sets are statistically similar (fail to reject that datasets are from the same distribution, p > 0.05)
 
#Low ID<sub>50</sub>/LD<sub>50</sub> (to obtain a conservative risk estimate)
 
 
 
We generally recommend a single dose response model, and we justify the decision in terms of the above criteria. This decision is somewhat subjective, since dose response datasets seldom meet all of these criteria. If all available models are unsatisfactory, we choose a single model to ‘recommend with reservations’. Our recommended model will seldom (if ever) be the best model for all applications. The user should carefully choose the model that is most appropriate for their particular problem.
 
 
 
= [[Dose Response (Home Page)|Back to Dose Response Home Page]] =
 
 
 
 
 
<headertabs />
 
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Revision as of 18:59, 12 June 2017

 Best Fit ModelParameterN50HostAgent StrainRouteDoseDose UnitResponseReference
Bacillus Anthracis: Feeding Experiments
Bacillus anthracis
Bacillus anthracis: Dose Response Models
Burkholderia
Burkholderia pseudomallei: Dose Response Models
Campylobacter jejuni
Campylobacter jejuni and Campylobacter coli: Dose Response Models
Coxiella burnetii
Coxiella burnetii: Dose Response Models
Cyanobacteria
Enterohemorrhagic Escherichia coli (EHEC)
Escherichia coli
Escherichia coli enterohemorrhagic (EHEC): Dose Response Models
Escherichia coli: Dose Response Models
Francisella tularensis
Francisella tularensis: Dose Response Models
Legionella pneumophila
Legionella pneumophila: Dose Response Models
Listeria monocytogenes
Listeria monocytogenes (Death as response): Dose Response Models
Listeria monocytogenes (Infection): Dose Response Models
Listeria monocytogenes (Stillbirths): Dose Response Models
Mycobacterium avium
Mycobacterium avium: Dose Response Models
Pseudomonas aeruginosa
Pseudomonas aeruginosa (Contact lens): Dose Response Models
Pseudomonas aeruginosa (bacterimia): Dose Response Models
Rickettsia rickettsi: Dose Response Models
Rickettsia rickettsii
Salmonella
Salmonella Typhi: Dose Response Models
Salmonella anatum: Dose Response Models
Salmonella enterica (nontyphoid)
Salmonella meleagridis: Dose Response Models
Salmonella nontyphoid: Dose Response Models
Salmonella serotype newport: Dose Response Models
Shigella sp.
Shigella: Dose Response Models
Staphylococcus aureus: Dose Response Models
Staphylococcus ayreus
TestPage
Variola major
Variola major: Dose Response Models
Vibrio cholerae
Vibrio cholerae: Dose Response Models
Yersinia pestis
Yersinia pestis: Dose Response Models