Difference between revisions of "Campylobacter jejuni"

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* Guillain-Barre syndrome (1-3/10,000)
 
* Guillain-Barre syndrome (1-3/10,000)
 
* Bacteremia (<1%)
 
* Bacteremia (<1%)
<br/>
 
 
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174097/ Feodoroff B.]
 
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174097/ Feodoroff B.]
  

Revision as of 14:34, 17 July 2012

Campylobacter jejuni

Host

Animals and humans

Transmission/Exposure Routes

Fecal-oral, ingestion of contaminated food or water, and the eating of raw meat

Case Fatality Ratio

Does not commonly cause death, it has been estimated that approximately 124 persons with Campylobacter infections die each year.

Case Fatality Ratio
Case Fatality Ratio Pathway/conditions Population References
0.19% (95% CI: 0.13-0.27%) Infected domestically (in Sweden)

Within first month following illness

Sweden [1]
0.008 (95% CI: 0.0008-0.03%) Infected Abroad (outside of Sweden)

Within first month following illness

Not Reported [1]
0.23% foodborne infection Denmark [2]

Incubation Period

3-5 days or up to a week [3]

Burden of Disease

It is estimated to affect over 2.4 million persons every year, or 0.8% of the population. [4]
In 2010, the CDC reported an incidence 13.6 per 100,000 for Campylobacteriosis. [5]

Duration of infectiousness and disease

Symptoms typically reside in one week. Antibiotic treatment has been shown to decrease the duration of intestinal symptoms by 1.32 Days (95% CI: 0.64-1.99) However, because of drug resistance problems, antibiotics are only advised in complicated cases.[6]

Symptomology

Illness can cause symptoms beginning 2-5 days after exposures. These symptoms include abdominal pain, cramping, diarrhea, and fever.

Post-infectious complications include...

  • Reactive Arthritis (7%)
  • Guillain-Barre syndrome (1-3/10,000)
  • Bacteremia (<1%)

Feodoroff B.

Excretion Rates (see Exposure)

Immunity

Microbiology

Gram-negative, spiral, and microaerophilic. Motile, with either unipolar or bipolar flagella, the organisms have a characteristic spiral/corkscrew appearance and are oxidase-positive

Environmental Survival


Recommended Dose Response Model

Dose response models for Campylobacter
Beta-Poisson, α is 0.14, N50 is 890.38

Betapoisson model.jpg





References

Campylobacter Wiki Page

  1. 1.0 1.1 Ternhag, A., Törner, A., Svensson, Å., Giesecke, J., & Ekdahl, K. (2005). Mortality following Campylobacter infection: a registry-based linkage study. BMC Infectious Diseases, 5, 70. doi:10.1186/1471-2334-5-70 Full Text
  2. Helms, M., Vastrup, P., Gerner-Smidt, P., & Mølbak, K. (2003). Short and long term mortality associated with foodborne bacterial gastrointestinal infections: registry based study. BMJ : British Medical Journal, 326(7385), 357. Full Text
  3. Medscape Page
  4. CDC Page
  5. Vital Signs: Incidence and Trends of Infection with Pathogens Transmitted Commonly Through Food --- Foodborne Diseases Active Surveillance Network, 10 U.S. Sites, 1996--2010. (n.d.). http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6022a5.htm?s_cid=mm6022a5_w
  6. Ternhag, A., Asikainen, T., Giesecke, J., & Ekdahl, K. (2007). A Meta-Analysis on the Effects of Antibiotic Treatment on Duration of Symptoms Caused by Infection with Campylobacter Species. Clinical Infectious Diseases, 44(5), 696–700. doi:10.1086/509924 Full Text