Listeria monocytogenes (Death as response): Dose Response Models
Contents
Listeria monocytogenes (Death as response)
General overview of Listeria monocytogenes
Listeria monocytogenes is a Gram-positive rod-shaped bacterium. It is the causative agent of listeriosis, a serious infection caused by eating food contaminated with the bacteria. The disease generally affects older adults, pregnant women, newborns, and adults with weakened immune systems. However, rarely, persons without these risk factors can also be affected (CDC 2012; Todar 2012).
The overt form of the disease has mortality greater than 25 percent. The two main clinical manifestations are sepsis and meningitis. Meningitis is often complicated by encephalitis, a pathology that is unusual for bacterial infections (Todar 2012).
Summary Data
Czuprynski et al. ( 2003) studied susceptibility of C57BL/6 mice and A/J mice to Listeria monocytogenes (strain Scott A) inoculating them intragastrically (Czuprynski, Faith et al. 2003). Similarly, Golnazarian et al. (1989) also compared infectious dose in normal and compromised C57BL/6J mice with pathogens( strain F5817) via oral route (Golnazarian, Donnelly et al. 1989).
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Optimization Output for experiment 291
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Optimization Output for experiment 293
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Optimization Output for experiment 294
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Summary
Although different experiments resulted into different risk the the experiment 291 was preferred as model for death as an endpoint of experiment.
References
- ↑ Golnazarian, C. A., C. W. Donnelly, et al. (1989). "Comparison of infectious dose of Listeria monocytogenes F5817 as determined for normal versus compromised C57B1/6J mice." Journal of food protection 52(10): 696-701.
- ↑ 2.0 2.1 Czuprynski, C. J., N. G. Faith, et al. (2003). "A/J Mice Are Susceptible and C57BL/6 Mice Are Resistant to Listeria monocytogenes Infection by Intragastric Inoculation." Infection and Immunity 71(2): 682-689.
- ↑ 3.0 3.1 3.2 Golnazarian, C. A., C. W. Donnelly, et al. (1989). "Comparison of infectious dose of Listeria monocytogenes F5817 as determined for normal versus compromised C57B1/6J mice." Journal of food protection 52(10): 696-701 Cite error: Invalid
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CDC (2012) "Listeria (Listeriosis)."
Smith, M. A., K. Takeuchi, et al. (2008). "Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates." Infection and Immunity 76(2): 726-731.
Todar, K. (2012). Todar's Online Textbook of Bacteriology.
Czuprynski, C. J., N. G. Faith, et al. (2003). "A/J Mice Are Susceptible and C57BL/6 Mice Are Resistant to Listeria monocytogenes Infection by Intragastric Inoculation." Infection and Immunity 71(2): 682-689.
Golnazarian, C. A., C. W. Donnelly, et al. (1989). "Comparison of infectious dose of Listeria monocytogenes F5817 as determined for normal versus compromised C57B1/6J mice." Journal of food protection 52(10): 696-701.