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Human and animal

Fecal-oral, indirectly through contact with dirty hands or objects

Case fatality ratios
Case Fatality Ratio Pathway/conditions Population References
0.03% Chinese (2008-2009) [1]
5-7% Pre-vaccine era [2]

3-10 days [2]

Hand, Foot, and Mouth Disease caused by enterovirus in China between 2008 and 2009 was studied and the incidence rate was 57.9%[1]

Duration of infectiousness and disease



Asymptomatic Rates

Excretion Rates (see Exposure)


Member of the picornavirus family, a large and diverse group of small RNA viruses characterized by a single positive-strand genomic RNA, icosahedral nonenveloped viruses that are approximately 30 nm in diameter[3]

Enteroviruses resist lipid solvents, ether, chloroform, and alcohol. They are inactivated at temperatures above 50°C but remain infectious at refrigerator temperature.[2]


  1. 1.0 1.1 ZHANG Jing, SUN JunLing, CHANG ZhaoRui, ZHANG WeiDong, WANG ZiJun, and FENG ZiJian. (2011) Characterization of Hand, Foot, and Mouth Disease in China between 2008 and 2009. Biomed Environ Sci, 24(3): 214‐221 Full Text
  2. 2.0 2.1 2.2 http://emedicine.medscape.com/article/217146-overview#showall
  3. http://en.wikipedia.org/wiki/Enterovirus